Efficient delivery of intact phosphodiester oligonucleotides by poly-β-amino esters
نویسندگان
چکیده
منابع مشابه
A bioreducible linear poly(β-amino ester) for siRNA delivery.
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[reaction: see text] H-Phosphonate monomers of 2'-O-(2-methoxyethyl) ribonucleosides have been synthesized. Oxidation of oligonucleotide H-phosphonates has been optimized to allow the synthesis of oligonucleotides containing either 2'-deoxy or 2'-O-(2-methoxyethyl) ribonucleoside residues combined with three different phosphate modifications in the backbone, i.e., phosphodiester (PO), phosphoro...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2010
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2010.01.028